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Summary of the Mean PF614 and <t> Oxycodone </t> C max and AUC 0–24 in Rat Plasma on Day 1 and 14
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Summary of the Mean PF614 and Oxycodone C max and AUC 0–24 in Rat Plasma on Day 1 and 14

Journal: Regulatory toxicology and pharmacology : RTP

Article Title: Nonclinical Safety Assessment of PF614: a Novel TAAP Prodrug of Oxycodone for Chronic Pain Indication

doi: 10.1016/j.yrtph.2019.104433

Figure Lengend Snippet: Summary of the Mean PF614 and Oxycodone C max and AUC 0–24 in Rat Plasma on Day 1 and 14

Article Snippet: Furthermore, dog tends to tolerate higher exposure to PF614 and oxycodone as compared to rat.. Oxycodone toxicity data of 10 (in rat), 28 Day, and 3 months (in rat and dog) studies (Product MSDS for OxyContin® Oxycodone HCl Controlled Release Tablets, 10 mg, Purdue Pharma L. P., 2008 , 2010) resemble clinical signs of PF614 such as labored breathing (rat) and salivation (dog) supporting the prodrug bioactivation.

Techniques: Clinical Proteomics

Summary of the Mean PF614 and Oxycodone C max and AUC 0–24 in Dog Plasma on Day 1 and 14

Journal: Regulatory toxicology and pharmacology : RTP

Article Title: Nonclinical Safety Assessment of PF614: a Novel TAAP Prodrug of Oxycodone for Chronic Pain Indication

doi: 10.1016/j.yrtph.2019.104433

Figure Lengend Snippet: Summary of the Mean PF614 and Oxycodone C max and AUC 0–24 in Dog Plasma on Day 1 and 14

Article Snippet: Furthermore, dog tends to tolerate higher exposure to PF614 and oxycodone as compared to rat.. Oxycodone toxicity data of 10 (in rat), 28 Day, and 3 months (in rat and dog) studies (Product MSDS for OxyContin® Oxycodone HCl Controlled Release Tablets, 10 mg, Purdue Pharma L. P., 2008 , 2010) resemble clinical signs of PF614 such as labored breathing (rat) and salivation (dog) supporting the prodrug bioactivation.

Techniques: Clinical Proteomics

Summary of the Mean PF614 and Oxycodone C max and AUC 0–24 in Rat Plasma on Day 1 and 14

Journal: Regulatory toxicology and pharmacology : RTP

Article Title: Nonclinical Safety Assessment of PF614: a Novel TAAP Prodrug of Oxycodone for Chronic Pain Indication

doi: 10.1016/j.yrtph.2019.104433

Figure Lengend Snippet: Summary of the Mean PF614 and Oxycodone C max and AUC 0–24 in Rat Plasma on Day 1 and 14

Article Snippet: Oxycodone was tested negative in Ames assay, positive for mouse lymphoma assay in presence of metabolic activation, weakly positive for human peripheral blood lymphocyte in-vitro chromosomal aberration assay, and was tested negative in in-vivo bone marrow micronucleus assay in mice (Product MSDS for OxyContin® Oxycodone HCl Controlled Release Tablets, 10 mg, Purdue Pharma L.P., 2008 , 2010).

Techniques: Clinical Proteomics

Summary of the Mean PF614 and Oxycodone C max and AUC 0–24 in Dog Plasma on Day 1 and 14

Journal: Regulatory toxicology and pharmacology : RTP

Article Title: Nonclinical Safety Assessment of PF614: a Novel TAAP Prodrug of Oxycodone for Chronic Pain Indication

doi: 10.1016/j.yrtph.2019.104433

Figure Lengend Snippet: Summary of the Mean PF614 and Oxycodone C max and AUC 0–24 in Dog Plasma on Day 1 and 14

Article Snippet: Oxycodone was tested negative in Ames assay, positive for mouse lymphoma assay in presence of metabolic activation, weakly positive for human peripheral blood lymphocyte in-vitro chromosomal aberration assay, and was tested negative in in-vivo bone marrow micronucleus assay in mice (Product MSDS for OxyContin® Oxycodone HCl Controlled Release Tablets, 10 mg, Purdue Pharma L.P., 2008 , 2010).

Techniques: Clinical Proteomics